Abstract

Primary intranasal transmissible venereal tumor is an uncommon manifestation of venereal tumor in sexually intact dogs. A two-year-old male non-descript dog was presented with a history of abnormal unilateral nasal swelling, sneezing, recurrent epistaxis, and unilateral mucohaemorrhagic nasal discharge for the past three weeks. During clinical examination, numerous friable masses attaching to the gums and infiltrating the nasal septum on the right side were observed. The skull radiograph revealed increased soft tissue density in the nasal cavity with osteolysis of the maxillary bone. Cytological examination of the mass revealed numerous neoplastic round cell populations with low-to moderate anisocytosis, anisokaryosis, a prominent mitotic figure, and abundant faint basophilic cytoplasm with unique punctate cytoplasmic vacuoles suggestive  of nasal form of transmissible venereal tumor (TVT). The dog was treated with vincristine sulphate at a dose rate of 0.025 mg/kg BW intravenously once weekly for a total of five doses, along with other supportive therapies After the second dose of vincristine therapy, the clinical signs continued to improve, and the dog achieved a smooth and uneventful recovery after completing five doses of vincristine therapy

Keywords : Intranasal, transmissible venereal tumor, osteolysis, cytology, vincristine sulphate