Abstract

Nanoparticles have emerged as versatile drug delivery vehicles suitable for a wide range of administration routes. Over time, researchers have explored numerous natural and synthetic polymers for nanoparticle preparation, with particular focus on Poly(lactic acid) (PLA), Poly(glycolic acid) (PGA), and their copolymers (PLGA) due to their favorable biocompatibility and biodegradability. These nanoparticles serve as carriers for various drug classes, including anticancer agents, antihypertensive drugs, immunomodulators, and hormones, as well as macromolecules like nucleic acids, proteins, peptides, and antibodies. This study investigates the impact of surfactant concentration on the size of poly(lactic-co-glycolic acid) (PLGA) nanoparticles. Through a systematic exploration of different surfactant concentrations, ranging from low to high levels, the size distribution of PLGA nanoparticles is analyzed using dynamic light scattering (DLS) or similar techniques. The abstract summarizes the observed relationship between surfactant concentration and nanoparticle size, providing insights into the optimal conditions for controlling PLGA nanoparticle size in various applications, from drug delivery to biomedical engineering.

Keywords : PLGA (poly lactide coglycolide), Pluronic F68, surfactant, Dynamic Light Scattering